生物
结核分枝杆菌
遗传学
全基因组测序
系统发育树
谱系(遗传)
基因组
基因
肺结核
结核分枝杆菌复合物
转移RNA
核糖核酸
医学
病理
作者
Tohru Miyoshi‐Akiyama,Kazuhito Satou,Masako Kato,Akino Shiroma,Kazunori Matsumura,Hinako Tamotsu,Hiroki Iwai,Kuniko Teruya,Keiji Funatogawa,Takashi Hirano,Teruo Kirikae
出处
期刊:Tuberculosis
[Elsevier]
日期:2015-01-01
卷期号:95 (1): 37-39
被引量:5
标识
DOI:10.1016/j.tube.2014.10.007
摘要
We report the completely annotated genome sequence of Mycobacterium tuberculosis (Zopf) Lehmann and Neumann (ATCC35812) (Kurono), which is a used for virulence and/or immunization studies. The complete genome sequence of M. tuberculosis Kurono was determined with a length of 4,415,078 bp and a G+C content of 65.60%. The chromosome was shown to contain a total of 4,340 protein-coding genes, 53 tRNA genes, one transfer messenger RNA for all amino acids, and 1 rrn operon. Lineage analysis based on large sequence polymorphisms indicated that M. tuberculosis Kurono belongs to the Euro-American lineage (lineage 4). Phylogenetic analysis using whole genome sequences of M. tuberculosis Kurono in addition to 22 M. tuberculosis complex strains indicated that H37Rv is the closest relative of Kurono based on the results of phylogenetic analysis. These findings provide a basis for research using M. tuberculosis Kurono, especially in animal models.
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