医学
肌萎缩侧索硬化
优势比
无创通气
气道
通风(建筑)
多元分析
内科学
气道阻塞
心脏病学
麻醉
机械通风
疾病
机械工程
工程类
作者
N. Vandenberghe,Anne‐Evelyne Vallet,Thierry Petitjean,P. Le Cam,Stéphane Peysson,Claude Guérin,Frédéric Dailler,Sylvie Jay,Vincent Cadiergue,Françoise Bouhour,Isabelle Court‐Fortune,Jean‐Philippe Camdessanché,Jean‐Christophe Antoine,F. Philit,Pascal Beuret,Sylvie Bin-Dorel,Christophe Vial,Emmanuel Broussolle
出处
期刊:Respiratory Care
[Daedalus Enterprises]
日期:2013-01-15
卷期号:58 (9): 1424-1432
被引量:38
标识
DOI:10.4187/respcare.02103
摘要
OBJECTIVE:
To assess factors that predict good tolerance of noninvasive ventilation (NIV), in order to improve survival and quality of life in subjects with amyotrophic lateral sclerosis. METHODS:
We conducted a prospective study in subjects with amyotrophic lateral sclerosis and requiring NIV. The primary end point was NIV tolerance at 1 month. Subjects, several of whom failed to complete the study, were classified as "tolerant" or "poorly tolerant," according to the number of hours of NIV use (more or less than 4 h per night, respectively). RESULTS:
Eighty-one subjects, 73 of whom also attended the 1-month follow-up visit, participated over 34 months. NIV tolerance after the first day of utilization predicted tolerance at 1 month (77.6% and 75.3% of subjects, respectively). Multivariate analysis disclosed 3 factors predicting good NIV tolerance: absence of airway secretions accumulation prior to NIV onset (odds ratio 11.5); normal bulbar function at initiation of NIV (odds ratio 8.5); and older age (weakly significant, odds ratio 1.1). CONCLUSION:
Our study reveals 3 factors that are predictive of good NIV tolerance, in particular the absence of airway secretion accumulation, which should prompt NIV initiation before its appearance.
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