细胞生物学
电池类型
胶原蛋白,I型,α1
化学
平滑肌
肌成纤维细胞
血管生成
细胞外基质
Ⅰ型胶原
细胞
病理
生物
纤维化
生物化学
癌症研究
内分泌学
医学
作者
C. Adrian Shuttleworth
标识
DOI:10.1016/s1357-2725(97)00033-2
摘要
Type VIII collagen is a product of endothelial cells, keratinocytes, mast cells, microvascular endothelial cells and some tumour cells. It is also present in a variety of extracellular matrices as diverse as sclera, skin and glomerulus. Type VIII molecules have a proposed chain composition of [α1(VIII)2 α2(VIII)]. While the function of collagen type VIII is uncertain recent work has highlighted the importance of this collagen in the vasculature. Particularly significant may be its up-regulation in smooth muscle cell migration and potential role in maintaining the smooth muscle cell phenotype. It is interesting to speculate that this collagen may provide a substratum for a variety of cells and facilitate movement of endothelial cells in angiogenesis, smooth muscle cells in intimal invasion and myofibroblasts in fibrotic conditions.
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