衣原体
生物
衣原体
毒力
基因组
微生物学
基因
衣原体
病毒学
遗传学
作者
Matthias Horn,Astrid Collingro,Stephan Schmitz‐Esser,Cora L. Beier,Ulrike Purkhold,Berthold Fartmann,Petra Brandt,Gerald J. Nyakatura,Marcus Droege,Dmitrij Frishman,Thomas Rattei,Hans‐Werner Mewes,Michael Wagner
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2004-04-13
卷期号:304 (5671): 728-730
被引量:418
标识
DOI:10.1126/science.1096330
摘要
Chlamydiae are the major cause of preventable blindness and sexually transmitted disease. Genome analysis of a chlamydia-related symbiont of free-living amoebae revealed that it is twice as large as any of the pathogenic chlamydiae and had few signs of recent lateral gene acquisition. We showed that about 700 million years ago the last common ancestor of pathogenic and symbiotic chlamydiae was already adapted to intracellular survival in early eukaryotes and contained many virulence factors found in modern pathogenic chlamydiae, including a type III secretion system. Ancient chlamydiae appear to be the originators of mechanisms for the exploitation of eukaryotic cells.
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