化学
催化作用
赫克反应
串联
苯甲酸
有机化学
醋酸
催化循环
级联反应
组合化学
钯
复合材料
材料科学
作者
Kelsey C. Miles,Chi “Chip” Le,James P. Stambuli
标识
DOI:10.1002/chem.201403561
摘要
Abstract The formation of exo ‐methylene indanones and indenones from simple ortho ‐allyl benzoic acid derivatives has been developed. Selective formation of the indanone or indenone products in these reactions is controlled by choice of ancillary ligand. This new process has a low environmental footprint as the products are formed in high yields using low catalyst loadings, while the only stoichiometric chemical waste generated from the reactants in the transformation is acetic acid. The conversion of the active cyclization catalyst into the Hermman–Beller palladacycle was exploited in a one‐pot tandem acyl Heck–Heck (aHH) reaction, and utilized in the synthesis of donepezil.
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