细胞内
纳米颗粒
表面改性
材料科学
纳米技术
肉豆蔻酰化
生物物理学
药物输送
膜
化学
生物化学
生物
物理化学
作者
Jae Sam Lee,Ching‐Hsuan Tung
标识
DOI:10.1002/adfm.201201345
摘要
Abstract Nanoparticles have great potential as nanotherapeutics, delivery vectors, and molecular imaging agents due to their flexible properties. Although intracellular and nuclear delivery of nanoparticles is desirable for therapeutic applications, it remains a challenge. Cell penetrating peptides (CPPs) are a powerful tool for the intracellular delivery of various cargoes. Here it is reported that functionalization of nanoparticles with a myristoylated oligoarginine CPP promotes cellular uptake without increased toxicity. It is evident that the myristoylated CPP is much more effective in transporting nanoparticles than the unmodified CPPs.
科研通智能强力驱动
Strongly Powered by AbleSci AI