Reward sensitivity and corticostriatal function during social rewards

心理学 腹侧纹状体 前额叶腹内侧皮质 颞顶交界 功能磁共振成像 前额叶皮质 纹状体 脑刺激奖励 物质使用 神经科学 发展心理学 认知 临床心理学 多巴胺 伏隔核
作者
James B. Wyngaarden,Camille Johnston,Daniel Sazhin,Jeffrey B. Dennison,Ori Zaff,Dominic S. Fareri,Michael McCloskey,Lauren B. Alloy,David V. Smith,Johanna M. Jarcho
标识
DOI:10.1101/2023.01.17.524305
摘要

Aberrant levels of reward sensitivity have been linked to substance use disorder and are characterized by alterations in reward processing in the ventral striatum (VS). Less is known about how reward sensitivity and subclinical substance use relate to striatal function during social rewards (e.g., positive peer feedback). Testing this relation is critical for predicting risk for development of substance use disorder. In this pre-registered study, participants (N=44) underwent fMRI while completing well-matched tasks that assess neural response to reward in social and monetary domains. Contrary to our hypotheses, aberrant reward sensitivity blunted the relationship between substance use and striatal activation during receipt of rewards, regardless of domain. Moreover, exploratory whole-brain analyses showed unique relations between substance use and social rewards in temporoparietal junction. Psychophysiological interactions demonstrated that aberrant reward sensitivity is associated with increased connectivity between the VS and ventromedial prefrontal cortex during social rewards. Finally, we found that substance use was associated with decreased connectivity between the VS and dorsomedial prefrontal cortex for social rewards, independent of reward sensitivity. These findings demonstrate nuanced relations between reward sensitivity and substance use, even among those without substance use disorder, and suggest altered reward-related engagement of cortico-VS responses as potential predictors of developing disordered behavior.
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