分子印迹聚合物
检出限
循环伏安法
电化学气体传感器
介电谱
微分脉冲伏安法
重复性
材料科学
分析化学(期刊)
安培法
色谱法
电化学
化学
电极
选择性
有机化学
物理化学
催化作用
作者
Rana P. B. Singh,Meenakshi Singh
出处
期刊:Talanta open
[Elsevier]
日期:2023-08-01
卷期号:7: 100194-100194
被引量:8
标识
DOI:10.1016/j.talo.2023.100194
摘要
The excess use of artificial sweeteners poses a serious issue to the environment and human health. Acesulfame-K (Ace-K) is a non-nutritive artificial sweetener excessively used as an alternative sugar substitute in various foods and beverages. Here a simple, selective and rapid method to determine Ace-K in dietary products is proposed. In this study, a molecularly imprinted polymer (MIP) based electrochemical sensor is designed for the sensitive and selective determination of Ace-K. MIP was developed by the electropolymerization of ortho-phenylenediamine (o-PD) thin film around template molecules (Ace-K) on a glassy carbon electrode. Various parameters such as deposition cycle, template removal and rebinding parameters were optimized for sensor fabrication. The sensor was characterized after each stage of fabrication using cyclic voltammetry (CV), differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS) and atomic force microscopy (AFM) analysis. The MIP sensor exhibited wide linear range for the determination of Ace-K from 0.1 to 17.0 μM. The developed sensor attained the limit of detection (LOD) and limit of quantification (LOQ) of 0.35 µM and 1.2 µM, respectively. The applicability of the proposed sensor was examined for Ace-K determination in real samples. The MIP sensor exhibited excellent selectivity, repeatability, stability and commercialization potential for Ace-K detection.
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