神经调节
医学
神经病理性疼痛
刺激
脊髓损伤
脊髓
慢性疼痛
叙述性评论
脊髓刺激
脑深部刺激
神经科学
物理医学与康复
麻醉
物理疗法
心理学
重症监护医学
疾病
精神科
病理
帕金森病
内科学
作者
Roberta Bonomo,Giulio Bonomo,Emanuele Rubiu,Guglielmo Iess,Giacomo Cammarata,Niccolò Innocenti,Francesco Restelli,Jacopo Falco,Edoardo Porto,Alessia Amato,Edvin Zekaj,Vincenzo Levi
标识
DOI:10.1016/j.bas.2024.102781
摘要
Spinal cord stimulation is a widespread treatment of chronic neuropathic pain from different conditions. Several novel and improving technologies have been recently developed to increase the effect of neuromodulation in patients refractory to pharmacological therapy. To explore Spinal cord stimulation's mechanisms of action, indications, and management. The paper initially explores the mechanism of action of this procedure based on the generation of an electric field between electrodes placed on the posterior dural surface of the spinal cord probably interfering with the transmission of pain stimuli to the brain. Subsequently, the most consolidated criteria for selecting patients for surgery, which constitute a major issue of debate, were defined. Thereafter, the fundamental patterns of stimulation were summarized by exploring the advantages and side effects. Lastly, the most common side effects and the related management were discussed. Proper selection of the patient is of paramount importance to achieve the best results from this specific neuromodulation treatment. Regarding the different types of stimulation patterns, no definite evidence-based guideline exist on which is the most appropriate in relation to the specific type of neuropathic pain. Both burst stimulation and high-frequency stimulation are innovative techniques that reduce the risk of paresthesias compared with conventional stimulation. Novel protocols of stimulation (burst stimulation and high frequency) may improve the trade-off between therapeutic benefits and potential side effects. Likewise, decreasing the rates of hardware-related complications will be also useful to increase the employment of neuromodulation in clinical settings.
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