弗里德林
黄原酮
抗菌活性
阴沟肠杆菌
部
化学
产气肠杆菌
传统医学
立体化学
碳-13核磁共振
树皮(声音)
细菌
生物
生物化学
大肠杆菌
肠杆菌科
医学
生态学
三萜类
基因
遗传学
作者
Dayang Nurul Anisa Abang Heilman,Nor Hisam Zamakshshari,Vivien Yi Mian Jong,Audrey Yong Chee Hui,Mas Atikah Lizazman,Fauziah Ahmad
标识
DOI:10.1080/14786419.2024.2345752
摘要
In search for new metabolites from the stem bark of Calophyllum soulattri and Calophyllum gracilentum, led to the isolation of a new xanthone, soulaxanthone (1), along with four other known metabolites, euxanthone (2), calopolyanolide E (3), calanolide E (4) and friedelin (5). The structures of these compounds were identified and elucidated using spectroscopic techniques such as 1H NMR,13C NMR, COSY, DEPT, HSQC, HMBC, MS and FTIR. The antibacterial activities of compounds 1-5, as well as the extracts, were tested against five bacterial strains. Soulaxanthone (1) exhibited moderate activity against Pseudomonas aeruginosa with an MIC value of 25 µg/mL. Hexane (non-polar) extract from both plants exhibited moderate activity against Enterobacter cloacae (MIC = 250 µg/mL). Calopolyanolide E (3) and friedelin (5) showed bactericidal activity against Enterobacter cloacae (MBC = 50 µg/mL), thus the compounds have the potential to serve as a new lead for developing effective antibacterial medication.
科研通智能强力驱动
Strongly Powered by AbleSci AI