化学
新陈代谢
激进的
代谢途径
羟基自由基
生物化学
葡萄糖醛酸盐
环境化学
作者
Xiaolong Yu,Xu Jin,Meng Li,Yuanyuan Yu,Hang Liu,Rujin Zhou,Aiguo Yin,Junyi Shi,Jianteng Sun,Lizhong Zhu
标识
DOI:10.1016/j.envpol.2023.121352
摘要
Recently, sodium percarbonate (SPC) as a solid substitute for H2O2 has aroused extensive attention in advanced oxidation processes. In current work, the degradation kinetics and mechanisms of antibiotic sulfamethoxazole (SMX) by ultraviolet (UV) driven SPC system were explored. The removal efficiency of SMX was enhanced as the increasing dosage of SPC. Moreover, hydroxyl radical (•OH), carbonate radical (CO3•-) and superoxide radical (O2•-) were verified to be presented by scavenger experiments and •OH, CO3•- exhibited a significant role in SMX degradation. Reactions mediated by these radicals were affected by anions and natural organic matters, implying that an incomplete mineralization of SMX would be ubiquitous. The screening four intermediates and transformation patterns of SMX were verified by DFT analysis. Metabolomic analysis demonstrated that a decreasing negative effect in E. coli after 24 h exposure was induced by intermediates products. In detail, SMX interfered in some key functional metabolic pathways including carbohydrate metabolism, pentose and glucuronate metabolism, nucleotide metabolism, arginine and proline metabolism, sphingolipid metabolism, which were mitigated after UV/SPC oxidation treatment, suggesting a declining environmental risk of SMX. This work provided new insights into biological impacts of SMX and its transformation products and vital guidance for SMX pollution control using UV/SPC technology.
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