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Editorial FocusCores of Reproducibility in PhysiologyUnderstanding Takotsubo syndrome: first evaluate your mouse modelJohn D. Horowitz and Sven Y. SurikowJohn D. HorowitzCardiovascular Pathophysiology and Therapeutics Group, Basil Hetzel Institute for Translational Research, University of Adelaide, Adelaide, South Australia, Australia and Sven Y. SurikowCardiovascular Pathophysiology and Therapeutics Group, Basil Hetzel Institute for Translational Research, University of Adelaide, Adelaide, South Australia, AustraliaCardiology Unit, Lyell McEwin Hospital, Northern Adelaide Local Health Network, Adelaide, South Australia, AustraliaPublished Online:31 Mar 2023https://doi.org/10.1152/ajpheart.00051.2023This is the final version - click for previous versionMoreSectionsFull TextPDF (309 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations REFERENCES1. Ghadri JR, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJet al. International Expert Consensus Document on Takotsubo Syndrome (Part I): clinical characteristics, diagnostic criteria, and pathophysiology. Eur Heart J 39: 2032–2046, 2018. doi:10.1093/eurheartj/ehy076.Crossref | PubMed | ISI | Google Scholar2. Ong GJ, Girolamo O, Stansborough J, Nguyen TH, Horowitz JD. Incidence and clinical/laboratory correlates of early hypotension in takotsubo syndrome. ESC Heart Fail 8: 2009–2015, 2021. doi:10.1002/ehf2.13277.Crossref | PubMed | Google Scholar3. Neil C, Nguyen TH, Kucia A, Crouch B, Sverdlov A, Chirkov Y, Mahadavan G, Selvanayagam J, Dawson D, Beltrame J, Zeitz C, Unger S, Redpath T, Frenneaux M, Horowitz J. Slowly resolving global myocardial inflammation/oedema in Tako-Tsubo cardiomyopathy: evidence from T2-weighted cardiac MRI. Heart 98: 1278–1284, 2012. doi:10.1136/heartjnl-2011-301481.Crossref | PubMed | Google Scholar4. Scally C, Rudd A, Mezincescu A, Wilson H, Srivanasan J, Horgan G, Broadhurst P, Newby DE, Henning A, Dawson DK. 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Surikow SY, Nguyen TH, Stafford I, Chapman M, Chacko S, Singh K, Licari G, Raman B, Kelly DJ, Zhang Y, Waddingham MT, Ngo DT, Bate AP, Chua SJ, Frenneaux MP, Horowitz JD. Nitrosative stress as a modulator of inflammatory change in a model of Takotsubo syndrome. JACC Basic Transl Sci 3: 213–226, 2018. doi:10.1016/j.jacbts.2017.10.002.Crossref | PubMed | Google Scholar8. Hayashi T, Tiwary SK, Lim KRQ, Rocha-Resende C, Kovacs- A, Weinheimer C, Mann DL. Refining the reproducibility of a murine model of stress-induced cardiomyopathy. Am J Physiol Heart Circ Physiol 324: H229–H240, 2023. doi:10.1152/ajpheart.00684.2022.Link | Google Scholar9. Nguyen TH, Neil CJ, Sverdlov AL, Ngo DT, Chan WP, Heresztyn T, Chirkov YY, Tsikas D, Frenneaux MP, Horowitz JD. Enhanced NO signaling in patients with Takotsubo cardiomyopathy: short-term pain, long-term gain? Cardiovasc Drugs Ther 27: 541–547, 2013. doi:10.1007/s10557-013-6481-x.Crossref | PubMed | Google Scholar10. Nguyen TH, Liu S, Ong GJ, Stafford I, Frenneaux MP, Horowitz JD. Glycocalyx shedding is markedly increased during the acute phase of Takotsubo cardiomyopathy. Int J Cardiol 243: 296–299, 2017. doi:10.1016/j.ijcard.2017.04.085.Crossref | PubMed | Google Scholar Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation CollectionsAJP-Heart CollectionsCores of Reproducibility in PhysiologyThis collection represents best practice in physiology for a particular method or equipment that is in broad, common use. It was developed in response to the challenge to improve transparency and reproducibility in published research results. Related ArticlesRefining the reproducibility of a murine model of stress-induced reversible cardiomyopathy 23 Jan 2023American Journal of Physiology-Heart and Circulatory Physiology More from this issue > Volume 324Issue 5May 2023Pages H630-H632 Crossmark Copyright & PermissionsCopyright © 2023 the American Physiological Society.https://doi.org/10.1152/ajpheart.00051.2023PubMed36897752History Received 26 January 2023 Accepted 2 March 2023 Published online 31 March 2023 Published in print 1 May 2023 KeywordsinflammationisoproterenolmiceTakotsubo syndrome Metrics