Construction of a new dual-drug delivery system based on stimuli-responsive co-polymer functionalized D-mannose for chemotherapy of breast cancer

材料科学 共聚物 药物输送 聚合物 高分子化学 纳米复合材料 聚合 核化学 化学工程 纳米技术 化学 复合材料 工程类
作者
Hassan Namazi,Malihe Pooresmaeil,Roya Salehi
出处
期刊:European Polymer Journal [Elsevier]
卷期号:188: 111958-111958 被引量:8
标识
DOI:10.1016/j.eurpolymj.2023.111958
摘要

In this work, we aimed to prepare the new blue-emissive carbon dots (CDs)-supported glyco-copolymer brushes functionalized D-mannose for targeted co-anticancer drug delivery to the breast cancer cells. Typically, the N-isopropyl acrylamide (NIPAM) and maleic anhydride (MAH) were copolymerized on the silica functionalized CDs surface via free-radical polymerization (CDs-poly(NIPAM-co-MAH)). Then, the synthesized CDs-poly(NIPAM-co-MAH) was functionalized with D-mannose (CDs-poly(NIPAM-co-MAH)-D-Man). The success of the nanocomposite synthesis was approved via several common characterization techniques. Thermal gravimetric analysis (TGA) analysis determined the percentage of polymer brush summed with D-mannose (D-Man) at about 12%. The size of CDs-poly(NIPAM-co-MAH)-D-Man was obtained at 30–42 nm. Photoluminescence (PL) analysis obtained an emission peak at ∼442 nm under the excitation wavelength of 365 for the nanocomposite, representing its blue luminescence nature. Doxorubicin (DOX) and curcumin (CUR) were co-loaded respectively, about ∼62% and ∼38% on CDs-poly(NIPAM-co-MAH)-D-Man ([email protected]@CDs-poly(NIPAM-co-MAH)-D-Man). The prepared system exhibited controlled drug release behavior and good biocompatibility in the in vitro cellular tests. The percentage of the arrested cells in sub G1 phase for the treated cells with [email protected]@CDs-poly(NIPAM-co-MAH)-D-Man was 100 %, while it was 86.85% for free [email protected] which can approve the high efficiency of [email protected]@CDs-poly(NIPAM-co-MAH)-D-Man in cancer therapy. Overall, the results displayed that the prepared nanocomposite can be potentially proposed as an efficient carrier for controlled and targeted anticancer drug delivery along with bioimaging.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
3秒前
能干的顾完成签到,获得积分10
3秒前
樱桃发布了新的文献求助10
4秒前
小马甲应助彩色的以旋采纳,获得10
5秒前
5秒前
好学者完成签到 ,获得积分10
6秒前
左一完成签到,获得积分20
8秒前
Fly完成签到,获得积分20
8秒前
顾矜应助科研通管家采纳,获得10
9秒前
科研通AI2S应助科研通管家采纳,获得10
9秒前
充电宝应助科研通管家采纳,获得10
9秒前
9秒前
无花果应助科研通管家采纳,获得10
9秒前
10秒前
jianke完成签到,获得积分10
10秒前
10秒前
michaelxia完成签到 ,获得积分10
12秒前
顾矜应助悲凉的诺言采纳,获得10
12秒前
樱桃完成签到,获得积分10
13秒前
jianke发布了新的文献求助10
15秒前
彭于晏应助米团采纳,获得10
16秒前
xtutang完成签到 ,获得积分10
18秒前
19秒前
吴迪完成签到,获得积分10
20秒前
juni12应助CC采纳,获得10
20秒前
22秒前
23秒前
23秒前
吴迪发布了新的文献求助10
24秒前
26秒前
lingjuanwu发布了新的文献求助10
27秒前
清脆寒香发布了新的文献求助10
27秒前
27秒前
小九不太乖完成签到,获得积分10
27秒前
淡定蓝发布了新的文献求助10
28秒前
29秒前
hrt完成签到,获得积分20
29秒前
29秒前
31秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Microlepidoptera Palaearctica, Volumes 1 and 3 - 13 (12-Volume Set) [German] 1122
The Data Economy: Tools and Applications 1000
Diamonds: Properties, Synthesis and Applications 800
PraxisRatgeber Mantiden., faszinierende Lauerjäger. – Buch gebraucht kaufen 700
Mantiden - Faszinierende Lauerjäger – Buch gebraucht kaufen 700
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3097793
求助须知:如何正确求助?哪些是违规求助? 2749704
关于积分的说明 7605682
捐赠科研通 2401576
什么是DOI,文献DOI怎么找? 1274203
科研通“疑难数据库(出版商)”最低求助积分说明 616015
版权声明 599016