材料科学
共聚物
药物输送
聚合物
高分子化学
纳米复合材料
聚合
核化学
化学工程
纳米技术
化学
复合材料
工程类
作者
Hassan Namazi,Malihe Pooresmaeil,Roya Salehi
标识
DOI:10.1016/j.eurpolymj.2023.111958
摘要
In this work, we aimed to prepare the new blue-emissive carbon dots (CDs)-supported glyco-copolymer brushes functionalized D-mannose for targeted co-anticancer drug delivery to the breast cancer cells. Typically, the N-isopropyl acrylamide (NIPAM) and maleic anhydride (MAH) were copolymerized on the silica functionalized CDs surface via free-radical polymerization (CDs-poly(NIPAM-co-MAH)). Then, the synthesized CDs-poly(NIPAM-co-MAH) was functionalized with D-mannose (CDs-poly(NIPAM-co-MAH)-D-Man). The success of the nanocomposite synthesis was approved via several common characterization techniques. Thermal gravimetric analysis (TGA) analysis determined the percentage of polymer brush summed with D-mannose (D-Man) at about 12%. The size of CDs-poly(NIPAM-co-MAH)-D-Man was obtained at 30–42 nm. Photoluminescence (PL) analysis obtained an emission peak at ∼442 nm under the excitation wavelength of 365 for the nanocomposite, representing its blue luminescence nature. Doxorubicin (DOX) and curcumin (CUR) were co-loaded respectively, about ∼62% and ∼38% on CDs-poly(NIPAM-co-MAH)-D-Man ([email protected]@CDs-poly(NIPAM-co-MAH)-D-Man). The prepared system exhibited controlled drug release behavior and good biocompatibility in the in vitro cellular tests. The percentage of the arrested cells in sub G1 phase for the treated cells with [email protected]@CDs-poly(NIPAM-co-MAH)-D-Man was 100 %, while it was 86.85% for free [email protected] which can approve the high efficiency of [email protected]@CDs-poly(NIPAM-co-MAH)-D-Man in cancer therapy. Overall, the results displayed that the prepared nanocomposite can be potentially proposed as an efficient carrier for controlled and targeted anticancer drug delivery along with bioimaging.
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