染色质
基因组
计算生物学
染色体构象捕获
生物
人类基因组
DNA
基因
基因组组织
遗传学
基因表达
增强子
作者
Siqi Wang,Zhengyu Luo,Weiguang Li,Tengfei Hu,Zhongying Zhao,Michael G. Rosenfeld,Xiaoyuan Song
标识
DOI:10.1093/lifemedi/lnad012
摘要
Abstract Eukaryotic genomes are highly compacted in the cell nucleus. Two loci separated by a long linear distance can be brought into proximity in space through DNA-binding proteins and RNAs, which contributes profoundly to the regulation of gene expression. Recent technology advances have enabled the development and application of the chromosome conformation capture (3C) technique and a host of 3C-based methods that enable genome-scale investigations into changes in chromatin high-order structures during diverse physiological processes and diseases. In this review, we introduce 3C-based technologies and discuss how they can be utilized to glean insights into the impacts of three-dimensional (3D) genome organization in normal physiological and disease processes.
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