小龙虾
生物
造血
转录组
吞噬作用
免疫系统
螯虾属
细胞生物学
干细胞
细胞
电池类型
血细胞
免疫学
生态学
基因
基因表达
遗传学
作者
Irene Söderhäll,Erik Fasterius,Charlotta Ekblom,Kenneth Söderhäll
出处
期刊:iScience
[Elsevier]
日期:2022-08-01
卷期号:25 (8): 104850-104850
被引量:4
标识
DOI:10.1016/j.isci.2022.104850
摘要
Crustaceans constitute a species-rich and ecologically important animal group, and their circulating blood cells (hemocytes) are of critical importance in immunity as key players in pathogen recognition, phagocytosis, melanization, and antimicrobial defense. To gain a better understanding of the immune responses to different pathogens, it is crucial that we identify different hemocyte subpopulations with different functions and gain a better understanding of how these cells are formed. Here, we performed single-cell RNA sequencing of isolated hematopoietic tissue (HPT) cells and hemocytes from the crayfish Pacifastacus leniusculus to identify hitherto undescribed hemocyte types in the circulation and show that the circulating cells are more diversified than previously recognized. In addition, we discovered cell populations in the HPT with clear precursor characteristics as well as cells involved in iron homeostasis, representing a previously undiscovered cell type. These findings may improve our understanding of hematopoietic stem cell regulation in crustaceans and other animals.
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