Electrochemical aptasensor based on the engineered core-shell MOF nanostructures for the detection of tumor antigens

适体 生物传感器 纳米技术 癌胚抗原 抗原 材料科学 化学 癌症 分子生物学 生物 免疫学 遗传学
作者
Suliman Khan,William C. Cho,Afrooz Sepahvand,Sara Haji Hosseinali,Arif Hussain,Mohammad Mahdi Nejadi Babadaei,Majid Sharifi,Mojtaba Falahati,Laila A. Jaragh-Alhadad,Timo L.M. ten Hagen,Xin Li
出处
期刊:Journal of Nanobiotechnology [Springer Nature]
卷期号:21 (1) 被引量:13
标识
DOI:10.1186/s12951-023-01884-5
摘要

It is essential to develop ultrasensitive biosensors for cancer detection and treatment monitoring. In the development of sensing platforms, metal-organic frameworks (MOFs) have received considerable attention as potential porous crystalline nanostructures. Core-shell MOF nanoparticles (NPs) have shown different diversities, complexities, and biological functionalities, as well as significant electrochemical (EC) properties and potential bio-affinity to aptamers. As a result, the developed core-shell MOF-based aptasensors serve as highly sensitive platforms for sensing cancer biomarkers with an extremely low limit of detection (LOD). This paper aimed to provide an overview of different strategies for improving selectivity, sensitivity, and signal strength of MOF nanostructures. Then, aptamers and aptamers-modified core-shell MOFs were reviewed to address their functionalization and application in biosensing platforms. Additionally, the application of core-shell MOF-assisted EC aptasensors for detection of several tumor antigens such as prostate-specific antigen (PSA), carbohydrate antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), human epidermal growth factor receptor-2 (HER2), cancer antigen 125 (CA-125), cytokeratin 19 fragment (CYFRA21-1), and other tumor markers were discussed. In conclusion, the present article reviews the advancement of potential biosensing platforms toward the detection of specific cancer biomarkers through the development of core-shell MOFs-based EC aptasensors.
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