小RNA
椎间盘
生物
从长凳到床边
生物信息学
变性(医学)
神经科学
计算生物学
医学
病理
遗传学
解剖
基因
医学物理学
作者
Fariborz Ghaffarpasand,Sirous Sarhadi,Mohammad Hesam Alavi,Ali Rajabpour Sanati,Maryam Dehghankhalili
出处
期刊:Epigenomics
[Future Medicine]
日期:2023-03-01
卷期号:15 (5): 271-281
被引量:1
标识
DOI:10.2217/epi-2022-0277
摘要
Intervertebral disc degeneration (IDD) is the main cause of low back pain, which is a healthcare concern associated with high social and economic burden. The current medical and surgical therapies are inadequate and ineffective. Several miRNAs have been identified that modulate (via up- or down-regulation) the pathogenesis of IDD through various signaling pathways. Understanding the nature of this regulation and their signaling pathways will enable researchers to manipulate miRNA regulation to develop miRNA-based therapies. The development of miRNA-based therapies opens a future window through which to decrease the IDD process or regenerate the intervertebral disc. In the near future, the obstacles associated with miRNA-based therapies will be overcome and these therapies will move from the bench to the bedside.
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