Single Breath‐Hold MR Elastography for Fast Biomechanical Probing of Pancreatic Stiffness

医学 重复性 弹性成像 重复措施设计 核医学 人口 前瞻性队列研究 生物医学工程 放射科 超声波 内科学 数学 环境卫生 统计
作者
Anne‐Sophie van Schelt,Lukas M. Gottwald,Nienke Wassenaar,Jurgen H. Runge,Ralph Sinkus,Jaap Stoker,Aart J. Nederveen,Eric Schrauben
出处
期刊:Journal of Magnetic Resonance Imaging [Wiley]
卷期号:59 (2): 688-698 被引量:4
标识
DOI:10.1002/jmri.28773
摘要

Background Pancreatic ductal adenocarcinoma (PDAC) stromal disposition is thought to influence chemotherapy efficacy and increase tissue stiffness, which could be quantified noninvasively via MR elastography (MRE). Current methods cause position‐based errors in pancreas location over time, hampering accuracy. It would be beneficial to have a single breath‐hold acquisition. Purpose To develop and test a single breath‐hold three‐dimensional MRE technique utilizing prospective undersampling and a compressed sensing reconstruction (CS‐MRE). Study Type Prospective. Population A total of 30 healthy volunteers (HV) (31 ± 9 years; 33% male) and five patients with PDAC (69 ± 5 years; 80% male). Field Strength/Sequence 3‐T, GRE Ristretto MRE. Assessment First, optimization of multi breath‐hold MRE was done in 10 HV using four combinations of vibration frequency, number of measured wave‐phase offsets, and TE and looking at MRE quality measures in the pancreas head. Second, viscoelastic parameters delineated in the pancreas head or tumor of CS‐MRE were compared against (I) 2D and (II) 3D four breath‐hold acquisitions in HV (N = 20) and PDAC patients. Intrasession repeatability was assessed for CS‐MRE in a subgroup of healthy volunteers (N = 15). Statistical Tests Tests include repeated measures analysis of variance (ANOVA), Bland–Altman analysis, and coefficients of variation (CoVs). A P ‐value <.05 was considered statistically significant. Results Optimization of the four breath‐hold acquisitions resulted in 40 Hz vibration frequency, five wave‐phases, and echo time (TE) = 6.9 msec as the preferred method (4BH‐MRE). CS‐MRE quantitative results did not differ from 4BH‐MRE. Shear wave speed (SWS) and phase angle differed significantly between HV and PDAC patients using 4BH‐MRE or CS‐MRE. The limits of agreement for SWS were [−0.09, 0.10] m/second and the within‐subject CoV was 4.8% for CS‐MRE. Data Conclusion CS‐MRE might allow a single breath‐hold MRE acquisition with comparable SWS and phase angle as 4BH‐MRE, and it may still enable to differentiate between HV and PDAC. Level of Evidence: 2 Technical Efficacy Stage: 2
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