生物
生物膜
运动性
鞭毛
细胞生物学
形态发生
伞
共焦激光扫描显微镜
菌毛
细菌
基质(化学分析)
细胞外基质
卫星
生物物理学
微生物学
生物系统
大肠杆菌
基因
遗传学
材料科学
航空航天工程
工程类
复合材料
作者
Mireia Cordero,Namiko Mitarai,Liselotte Jauffred
出处
期刊:The ISME Journal
[Springer Nature]
日期:2023-08-17
卷期号:17 (11): 1819-1827
被引量:5
标识
DOI:10.1038/s41396-023-01494-x
摘要
Bacteria have spectacular survival capabilities and can spread in many, vastly different environments. For instance, when pathogenic bacteria infect a host, they expand by proliferation and squeezing through narrow pores and elastic matrices. However, the exact role of surface structures-important for biofilm formation and motility-and matrix density in colony expansion and morphogenesis is still largely unknown. Using confocal laser-scanning microscopy, we show how satellite colonies emerge around Escherichia coli colonies embedded in semi-dense hydrogel in controlled in vitro assays. Using knock-out mutants, we tested how extra-cellular structures, (e.g., exo-polysaccharides, flagella, and fimbria) control this morphology. Moreover, we identify the extra-cellular matrix' density, where this morphology is possible. When paralleled with mathematical modelling, our results suggest that satellite formation allows bacterial communities to spread faster. We anticipate that this strategy is important to speed up expansion in various environments, while retaining the close interactions and protection provided by the community.
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