静电纺丝
丝素
材料科学
生物相容性
纳米纤维
纳米复合材料
热重分析
复合数
聚氨酯
组织工程
接触角
化学工程
抗菌活性
纳米颗粒
扫描电子显微镜
银纳米粒子
丝绸
傅里叶变换红外光谱
复合材料
纳米技术
聚合物
生物医学工程
医学
生物
细菌
冶金
遗传学
工程类
作者
Rumysa Saleem Khan,Anjum Hamid Rather,Taha Umair Wani,Muheeb Rafiq,Sami‐ullah Rather,Arvind H. Jadhav,Maduraiveeran Hemavathi,Muzafar A. Kanjwal,Faheem A. Sheikh
标识
DOI:10.1002/adsu.202300109
摘要
Abstract The hydrophobicity of polyurethane fibers is undesired for tissue engineering. In this work, fibers are fabricated by electrospinning and coated with silk fibroin (SF) for biocompatibility and biologically synthesized silver (Ag) nanoparticles (NPs) for antibacterial activity. The scanning electron microscopy revealed the undistorted morphology and the presence of NPs on fibers. The Fourier transform infrared and thermogravimetric analysis show the successful incorporation of SF and Ag NPs. The water contact angle drops from 101.26±0.2° in pristine to 3.1±0.3° in the hydrothermally treated fibers. The moisture regain from 1.87±0.3% to 6.7±0.4% is observed after 24 h. The mineralization shows the hydroxyapatite NPs in all composites. The large zone of inhibition is observed in the composite, with the Ag NPs equal to 11.5±0.04 mm for Staphylococcus aureus and 18.91±0.02 mm for Escherichia coli . The increased proliferation of HEK 293T cells for 6 days of culture on composite scaffolds compared to the pristine scaffolds is achieved. The cell attachment examinations show successful attachment of cells on fibers and nuclear staining analysis shows the highest proliferation in scaffolds with an intermediate concentration of Ag NPs (10%). This strategy presents a novel improvisation for as‐spun PU fibers that can fabricate wound‐healing biomaterials for tissue engineering.
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