Stratification of Stage II Colon Cancer Using Recurrence Prediction Value

医学 价值(数学) 内科学 结直肠癌 阶段(地层学) 癌症 肿瘤科 肿瘤分期 癌症复发 危险分层 统计 数学 生物 古生物学
作者
Shodai Mizuno,Kohei Shigeta,Yujin Kato,Jun Okui,Satoru Morita,Swati Sonal,Robert N. Goldstone,David L. Berger,Rama AlMasri,Mahmoud Al-Masri,Yuki Tajima,Hiroto Kikuchi,Akira Hirata,Jumpei Nakadai,Hideo Baba,Kiyoaki Sugiura,Go Hoshino,Yuki Seo,Akitsugu Makino,Hirofumi Suzumura,Yoshiyuki Suzuki,Yoko Adachi,Takehiro Shimada,Takayuki Kondo,Shimpei Matsui,Ryo Seishima,Koji Okabayashi,Yuko Kitagawa,Hiroko Kunitake
出处
期刊:Annals of Surgery [Ovid Technologies (Wolters Kluwer)]
卷期号:280 (2): 274-282 被引量:1
标识
DOI:10.1097/sla.0000000000006120
摘要

Objective: To create a recurrence prediction value (RPV) of high-risk factor and identify the patients with high risk of cancer recurrence. Background: There are several high-risk factors known to lead to poor outcomes. Weighting each high-risk factor based on their association with increased risk of cancer recurrence can provide a more precise understanding of risk of recurrence. Methods: We performed a multi-institutional international retrospective analysis of patients with stage II colon cancer patients who underwent surgery from 2010 to 2020. Patient data from a multi-institutional database were used as the Training data, and data from a completely separate international database from 2 countries were used as the Validation data. The primary endpoint was recurrence-free survival. Results: A total of 739 patients were included from Training data. To validate the feasibility of RPV, 467 patients were included from Validation data. Training data patients were divided into RPV low (n=564) and RPV high (n=175). Multivariate analysis revealed that risk of recurrence was significantly higher in the RPV high than the RPV low [hazard ratio (HR) 2.628; 95% confidence interval (CI) 1.887–3.660; P <0.001). Validation data patients were divided into 2 groups (RPV low, n=420) and RPV high (n=47). Multivariate analysis revealed that risk of recurrence was significantly higher in the RPV high than the RPV low (HR 3.053; 95% CI 1.962–4.750; P <0.001). Conclusions: RPV can identify stage II colon cancer patients with high risk of cancer recurrence worldwide.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
栗子发布了新的文献求助20
1秒前
1秒前
acetdw完成签到,获得积分10
2秒前
学术混子发布了新的文献求助10
2秒前
悦之无因完成签到,获得积分10
2秒前
安静幻枫应助Joshua采纳,获得20
2秒前
3秒前
4秒前
xingxing完成签到,获得积分10
4秒前
4秒前
桐桐桐桐桐桐完成签到,获得积分10
4秒前
5秒前
啊的瓦房瓦房完成签到,获得积分20
6秒前
大模型应助liyu采纳,获得10
6秒前
7秒前
上官若男应助自觉馒头采纳,获得10
8秒前
XJ完成签到,获得积分10
8秒前
1117发布了新的文献求助10
8秒前
8秒前
礼岁岁完成签到 ,获得积分10
8秒前
Gong完成签到,获得积分10
9秒前
9秒前
9秒前
9秒前
acetdw发布了新的文献求助10
9秒前
impossible发布了新的文献求助10
11秒前
笑点低的云朵应助515采纳,获得20
11秒前
木槿完成签到 ,获得积分10
11秒前
11秒前
菜鸟完成签到,获得积分20
11秒前
可爱的函函应助Lynn采纳,获得10
11秒前
xiaooooo发布了新的文献求助10
11秒前
bkagyin应助Alice采纳,获得10
12秒前
12秒前
归尘应助xmh采纳,获得10
12秒前
tang发布了新的文献求助10
13秒前
安详的跳跳糖完成签到,获得积分10
13秒前
123应助栗子采纳,获得20
13秒前
无问发布了新的文献求助10
13秒前
tantalum发布了新的文献求助10
14秒前
高分求助中
Licensing Deals in Pharmaceuticals 2019-2024 3000
Effect of reactor temperature on FCC yield 2000
Very-high-order BVD Schemes Using β-variable THINC Method 1020
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Near Infrared Spectra of Origin-defined and Real-world Textiles (NIR-SORT): A spectroscopic and materials characterization dataset for known provenance and post-consumer fabrics 610
Mission to Mao: Us Intelligence and the Chinese Communists in World War II 600
Promoting women's entrepreneurship in developing countries: the case of the world's largest women-owned community-based enterprise 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3305528
求助须知:如何正确求助?哪些是违规求助? 2939246
关于积分的说明 8492531
捐赠科研通 2613686
什么是DOI,文献DOI怎么找? 1427569
科研通“疑难数据库(出版商)”最低求助积分说明 663114
邀请新用户注册赠送积分活动 647864