In people with type 2 diabetes, sarcopenia is associated with the incidence of cardiovascular disease: A prospective cohort study from the UK Biobank

肌萎缩 医学 危险系数 前瞻性队列研究 2型糖尿病 入射(几何) 内科学 糖尿病 冲程(发动机) 心肌梗塞 队列研究 队列 比例危险模型 生命银行 物理疗法 置信区间 内分泌学 生物信息学 工程类 物理 光学 生物 机械工程
作者
Jirapitcha Boonpor,Jill P. Pell,Frederick K. Ho,Carlos Celis‐Morales,Stuart R. Gray
出处
期刊:Diabetes, Obesity and Metabolism [Wiley]
卷期号:26 (2): 524-531 被引量:7
标识
DOI:10.1111/dom.15338
摘要

Abstract Aim To investigate the association of sarcopenia with cardiovascular disease (CVD) incidence in people with type 2 diabetes. Materials and Methods A prospective cohort study with 11 974 White European UK Biobank participants with type 2 diabetes, aged 40‐70 years, included. Sarcopenia was defined based on the European Working Group on Sarcopenia in Older People as either non‐sarcopenic or sarcopenic. Outcomes included CVD, stroke, heart failure (HF) and myocardial infarction (MI). The association between sarcopenia and the incidence of outcomes was investigated using Cox proportional hazard models adjusted for sociodemographic and lifestyle factors. The rate advancement period was used to estimate the time period by which CVD is advanced because of sarcopenia. Results Over a median follow‐up of 10.7 years, 1957 participants developed CVDs: 373 had a stroke, 307 had an MI and 742 developed HF. Compared with non‐sarcopenia, those with sarcopenia had higher risks of CVD (HR 1.89 [95% CI 1.61; 2.21]), HF (HR 2.59 [95% CI 2.12; 3.18]), stroke (HR 1.90 [95% CI 1.38; 2.63]), and MI (HR 1.56 [95% CI 1.04; 2.33]) after adjustment for all covariates. Those with sarcopenia had CVD incidence rates equivalent to those without sarcopenia who were 14.5 years older. Similar results were found for stroke, HF and MI. Conclusions In people with type 2 diabetes, sarcopenia increased the risk of developing CVD, which might occur earlier than in those without sarcopenia. Therefore, sarcopenia screening and prevention in patients with type 2 diabetes may be useful to prevent the complications of CVD.
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