不育
生物
表观遗传学
表型
遗传学
基因
遗传(遗传算法)
非孟德尔遗传
染色质
生殖系
线粒体DNA
作者
Chee Kiang Ewe,Oded Rechavi
标识
DOI:10.15252/embr.202358318
摘要
Disrupting the small RNA pathway and chromatin‐modifying enzymes in C. elegans often leads to a mortal germline (Mrt) phenotype, characterized by progressive sterility observed over multiple generations at elevated temperature. This phenotype arises from the inheritance of aberrant epigenetic memory across generations. In this issue of EMBO Reports, Frézal and colleagues reported that, while in standard laboratory environment C. elegans wild isolates exhibit the Mrt phenotype, sterility does not occur when the worms are exposed to naturally associated bacteria and microsporidia. Excitingly, diet‐induced epigenetic memory may persist for multiple generations. This suggests intriguing diet–gene interactions in modulating nongenetic inheritance, potentially shaping the evolutionary trajectory of the animals.
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