生物标志物
脉络丛
医学
脑脊液
蛋白质组学
基因沉默
癌症研究
神经科学
生物信息学
病理
细胞生物学
生物
生物化学
中枢神经系统
基因
作者
Juncao Chen,Lin Wang,Xiangwen Peng,Tingting Cheng,Yihui Yang,Jin‐Ying Su,Hongmei Zou,Siyao Wang,Y. Mao,Linzhan Wu,Xuntao Yin,Minxu Li,Mingwei Zhu,Wei Zhou
标识
DOI:10.1002/advs.202410056
摘要
Intraventricular hemorrhage in preterm neonates has become a major global health problem and is associated with a high risk of post-hemorrhagic hydrocephalus (PHH). Identifying diagnostic markers and therapeutic targets is a focal challenge in the PHH prevention and control. Here, this study applies multi-omics analyses to characterize the biochemical, proteomic, and metabolomic profiles of the cerebrospinal fluid (CSF) in clinical human cohorts to investigate disease development and recovery processes occurring due to PHH. Integrative multiomics analysis suggests that the over-representation of ferroptosis, calcium, calcium ion binding, and cell adhesion signaling pathways is associated with PHH. Bioinformatic analysis indicates that chondroitin sulfate proteoglycan 4 (CSPG4) is discovered as a CSF biomarker and positively correlated with the ventricular size and the rate of periventricular leukomalacia. Next, it is further demonstrated that these signaling pathways are dysregulated in the choroid plexus (ChP) in PHH by using in vitro cellular experiments and rat models of PHH, whereas CSPG4 silencing can suppress ferroptosis, cell adhesion function, and the intracellular flow of Ca
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