脚手架
材料科学
生物医学工程
再生(生物学)
再生医学
组织工程
伤口愈合
瘢痕组织
自愈水凝胶
弹性模量
复合材料
医学
外科
细胞生物学
干细胞
生物
高分子化学
作者
Yangwang Jin,Ying Wang,Ranxing Yang,Weishan Fang,Kaile Zhang,Meng Liu,Yuhui Wang,Ming Yang,Qiang Fu
出处
期刊:Biomaterials
[Elsevier]
日期:2024-07-01
卷期号:: 122711-122711
标识
DOI:10.1016/j.biomaterials.2024.122711
摘要
The unsuitable deformation stimulus, harsh urine environment, and lack of a regenerative microenvironment (RME) prevent scaffold-based urethral repair and ultimately lead to irreversible urethral scarring. The researchers clarify the optimal elastic modulus of the urethral scaffolds for urethral repair and design a multilayered PVA hydrogel scaffold for urethral scar-free healing. The inner layer of the scaffold has self-healing properties, which ensures that the wound effectively resists harsh urine erosion, even when subjected to sutures. In addition, the scaffold's outer layer has an extracellular matrix-like structure that synergizes with adipose-derived stem cells to create a favorable RME. In vivo experiments confirm successful urethral scar-free healing using the PVA multilayered hydrogel scaffold. Further mechanistic study shows that the PVA multilayer hydrogel effectively resists the urine-induced inflammatory response and accelerates the transition of urethral wound healing to the proliferative phase by regulating macrophage polarization, thus providing favorable conditions for urethral scar-free healing. This study provides mechanical criteria for the fabrication of urethral tissue-engineered scaffolds, as well as important insights into their design.
科研通智能强力驱动
Strongly Powered by AbleSci AI