免疫疗法
癌症
癌症免疫疗法
免疫系统
T细胞
黑色素瘤
癌症研究
临床试验
医学
免疫学
内科学
作者
Adrian Hayday,Julie Déchanet‐Merville,Jamie Rossjohn,Bruno Silva‐Santos
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-10-03
卷期号:386 (6717)
标识
DOI:10.1126/science.abq7248
摘要
The premise of cancer immunotherapy is that cancers are specifically visible to an immune system tolerized to healthy self. The promise of cancer immunotherapy is that immune effector mechanisms and immunological memory can jointly eradicate cancers and inoperable metastases and de facto vaccinate against recurrence. For some patients with hitherto incurable diseases, including metastatic melanoma, this promise is being realized by game-changing immunotherapies based on αβ T cells. Today's challenges are to bring benefit to greater numbers of patients of diverse ethnicities, target more cancer types, and achieve a cure while incurring fewer adverse events. In meeting those challenges, specific benefits may be offered by γδ T cells, which compose a second T cell lineage with distinct recognition capabilities and functional traits that bridge innate and adaptive immunity. γδ T cell-based clinical trials, including off-the-shelf adoptive cell therapy and agonist antibodies, are yielding promising results, although identifiable problems remain. In addressing those problems, we advocate that immunotherapies be guided by the distinctive biology of γδ T cells, as elucidated by ongoing research.
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