溶血磷脂酰胆碱
溶血磷脂酰乙醇胺
酮发生
脂类学
化学
脂质体
油菜
生物化学
内科学
食品科学
内分泌学
酮体
生物
医学
新陈代谢
磷脂酰胆碱
磷脂
膜
作者
Teng Wei,Yangzheng He,Tan Dengfeng,Xiaoling Zeng,Yanmei Hou,Jiaqi Wang,Hui Jiang,Zeyuan Deng,Jing Li
标识
DOI:10.1016/j.foodchem.2024.140955
摘要
Investigations indicated that sn-2 palmitate have positive effects on brain development, although its mechanism remains largely unexamined. This research delved into how a diet abundant in sn-2 palmitate influenced the cognitive behavior of mice and elucidated the associated mechanisms using metabolomics and lipidomics. The study demonstrated that dietary sn-2 palmitate led to improved working memory and cognition in mice, as well as an increase in brain BDNF concentration when compared to those fed blend vegetable oil (BVO). This was because sn-2 palmitate feeding promoted the synthesis of very long-chain fatty acids (VLCPUFAs) for the lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE) in the liver. This led to more efficient delivery of VLCPUFAs to the brain, as indicated by elevated concentration of LPC/LPE-VLCPUFAs in the liver and heightened expression of the major facilitator superfamily domain containing 2a (MFSD2A). In essence, this paper offered a potential mechanism by which sn-2 palmitate enhanced mouse neurodevelopment.
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