化学
铋
细胞
生物物理学
纳米技术
细胞生物学
生物化学
材料科学
生物
有机化学
作者
Jeremy L. Ritchey,Luca Filippi,David H. Ballard,Dehua Pei
标识
DOI:10.1021/acs.molpharmaceut.4c00688
摘要
Intracellular delivery of biological cargos, which would yield new research tools and novel therapeutics, remains an active area of research. A convenient and potentially general approach involves the conjugation of a cell-penetrating peptide to a cargo of interest. However, linear CPPs lack sufficient cytosolic entry efficiency and metabolic stability, while previous backbone cyclized CPPs have several drawbacks including the necessity for chemical synthesis and posttranslational conjugation to peptide/protein cargos and epimerization during cyclization. We report here a new class of bismuth cyclized CPPs with excellent cytosolic entry efficiencies, proteolytic stability, and potential compatibility with genetic encoding and recombinant production.
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