化学
噻唑烷
对偶(语法数字)
组合化学
生物化学
立体化学
计算生物学
药理学
医学
生物
文学类
艺术
作者
Jiabing Long,Hongjuan Chen,Zhenxin Yan,Le Zhou,Renhua Deng,Jie Wang,Zilong Tang,Yichao Wan
标识
DOI:10.1016/j.bioorg.2024.107687
摘要
Increasing the levels of antiapoptotic Bcl-2 proteins is an important way that cancer cells utilize to get out of apoptosis, underscoring their significance as promising targets for anticancer therapies. Lately, a primary compound 1 bearing thiazolidine-2,4-dione was discovered to exhibit comparable Mcl-1 inhibitory activity in comparison to WL-276. Herein, thirty-nine thiazolidine-2,4-dione analogs were yielded through incorporating different biphenyl moieties (R
科研通智能强力驱动
Strongly Powered by AbleSci AI