苦恼
癌症
社会心理的
癌变
医学
心理神经免疫学
心理肿瘤学
心理困扰
心理压力
心理学
生物信息学
临床心理学
肿瘤科
心理治疗师
内科学
精神科
焦虑
生物
免疫学
免疫系统
作者
Yuanjun Wu,Laiyan Zhou,Xuanwei Zhang,Xue Yang,Gabriele Niedermann,Jianxin Xue
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2022-11-23
卷期号:8 (47)
被引量:22
标识
DOI:10.1126/sciadv.abq7982
摘要
Facing cancer diagnosis, patients with cancer are prone to psychological stress and consequent psychological disorders. The association between psychological stress and cancer has long been a subject of high interest. To date, preclinical studies have gradually uncovered the promotive effects of psychological distress on tumor hallmarks. In contrast, eustress may exert suppressive effects on tumorigenesis and beneficial effects on tumor treatment, which brings a practicable means and psychosocial perspective to cancer treatment. However, the underlying mechanisms remain incompletely understood. Here, by focusing on the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system, as well as stress-related crucial neurotransmitters and hormones, we highlight the effects of distress and eustress on tumorigenesis, the tumor microenvironment, and tumor treatment. We also discuss the findings of clinical studies on stress management in patients with cancer. Last, we summarize questions that remain to be addressed and provide suggestions for future research directions.
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