Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Our study provides a valuable resource, including a dynamic single-cell landscape and a robust colorectal cancer sc-eQTL atlas, and elucidates the cell type-specific regulation and important cross-talk mechanisms between cell types in the tumor microenvironment, offering deep insights into colorectal cancer tumorigenesis and targeted therapies.