亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Association between driving pressure and postoperative pulmonary complications in patients undergoing lung resection surgery: A randomised clinical trial

医学 麻醉 肺癌 机械通风 呼气末正压 潮气量 随机对照试验 肺癌手术 外科 内科学 呼吸系统
作者
Junjie Yu,Wu Zhi,Rui An,Huiting Li,Tianhua Zhang,Wenqian Lin,Hongying Tan,Longhui Cao
出处
期刊:Anaesthesia, critical care & pain medicine [Elsevier BV]
卷期号:42 (1): 101160-101160 被引量:4
标识
DOI:10.1016/j.accpm.2022.101160
摘要

It is uncertain whether an association exists for decreases in driving pressure and the occurrence of postoperative pulmonary complications (PPCs) in patients undergoing selective lung resection surgery. Thus, we designed this study to determine whether the positive end-expiratory pressure (PEEP) titration to the lowest driving pressure compared with conventional low PEEP level during one-lung ventilation (OLV) in patients undergoing selective lung resection surgery decreases PPCs.This single-centre, randomised trial approved by the Ethical Committee of the Sun Yat-Sen University Cancer Center involved patients who signed written consent. Patients were randomised to the PEEP titration to the lowest driving pressure group (n = 104), or to the conventional low level of PEEP group (n = 103), consisting a PEEP level of 4 cm H2O during OLV. All patients received volume-controlled ventilation with a tidal volume of 6 mL/kg of predicted body weight. The primary outcome was defined as positive if 4 or more of eight Melbourne Group Scale (MGS) variables developed within the first 3 days after surgery. The incidence of major PPCs occurring during postoperative 7 days was also recorded.Among 222 patients who were randomised, 207 (93%) completed the trial (109 men [53%]; mean age, 56.9 years). The primary outcome occurred in 4 of 104 patients (4%) in the PEEP titration to the lowest driving pressure group compared with 13 of 103 patients (13%) in the conventional low level of PEEP group (risk ratio, 0.32 [95% CI, 0.10-0.90]; P = 0.021).Among patients undergoing selective lung surgery, intraoperative OLV with PEEP titration to the lowest driving pressure compared with conventional low PEEP level (4 cm H2O) significantly reduced PPCs within the first 3 postoperative days, however, did not significantly reduce PPCs within the first 7 postoperative days.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
14秒前
迷茫的一代完成签到,获得积分10
50秒前
52秒前
量子星尘发布了新的文献求助10
1分钟前
1分钟前
1分钟前
无私的薯片完成签到,获得积分20
1分钟前
科研通AI2S应助科研通管家采纳,获得30
1分钟前
无花果应助科研通管家采纳,获得10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
可爱的函函应助Lorain采纳,获得10
1分钟前
2分钟前
huangwensou发布了新的文献求助30
2分钟前
5Hepburn发布了新的文献求助10
2分钟前
ZXH发布了新的文献求助10
2分钟前
5Hepburn完成签到,获得积分20
2分钟前
2分钟前
2分钟前
李健的小迷弟应助凉白开采纳,获得10
2分钟前
钟垠州完成签到 ,获得积分10
3分钟前
量子星尘发布了新的文献求助10
3分钟前
3分钟前
Lorain发布了新的文献求助10
3分钟前
herococa完成签到,获得积分0
3分钟前
3分钟前
3分钟前
3分钟前
3分钟前
Lorain发布了新的文献求助10
4分钟前
隐形曼青应助Lorain采纳,获得10
4分钟前
krajicek发布了新的文献求助10
4分钟前
Lorain发布了新的文献求助10
4分钟前
量子星尘发布了新的文献求助10
4分钟前
4分钟前
凉白开发布了新的文献求助10
4分钟前
4分钟前
Lorain发布了新的文献求助10
4分钟前
5分钟前
5分钟前
5分钟前
高分求助中
The Mother of All Tableaux Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 2400
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind (Sixth Edition) 1000
Optimal Transport: A Comprehensive Introduction to Modeling, Analysis, Simulation, Applications 800
Official Methods of Analysis of AOAC INTERNATIONAL 600
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 588
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3960135
求助须知:如何正确求助?哪些是违规求助? 3506271
关于积分的说明 11128683
捐赠科研通 3238299
什么是DOI,文献DOI怎么找? 1789684
邀请新用户注册赠送积分活动 871870
科研通“疑难数据库(出版商)”最低求助积分说明 803069