化学
拉曼散射
鼻咽癌
拉曼光谱
纳米技术
光学
内科学
放射治疗
医学
物理
材料科学
作者
Mengmeng Zheng,Yahui Ren,Lei Jing,M. L. Cheng,Juqiang Lin,Yun Yu
标识
DOI:10.1016/j.aca.2024.342864
摘要
Nasopharyngeal carcinoma (NPC) is a malignant epithelial carcinoma arising from the nasopharyngeal mucosal lining. Diagnosis of NPC at early stage can improve the outcome of patients and facilitate reduction in cancer mortality. The most significant change between cancer cells and normal cells is the variation of cell nucleus. Therefore, accurately detecting the biochemical changes in nucleus between cancer cells and normal cells has great potential to explore diagnostic molecular markers for NPC. Highly sensitive surface-enhanced Raman scattering (SERS) could reflect the biochemical changes in the process of cell cancerization at the molecular level. However, rapid nuclear targeting SERS detection remains a challenge.
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