平衡
视黄醇
肥胖
铁稳态
生物
医学
细胞生物学
内分泌学
维生素
新陈代谢
作者
Marie F. Kiefer,Yueming Meng,Na Yang,Madita Vahrenbrink,Sascha Wulff,Chen Li,Sylvia J. Wowro,Konstantin M. Petricek,Manuela Sommerfeld,Roberto E. Flores,Benedikt Obermayer,Karolin Weitkunat,К. Schimrigk,Kimberly Hartl,Adrien Guillot,Frank Tacke,Michael Sigal,Michael Schupp
出处
期刊:American Journal of Physiology-endocrinology and Metabolism
[American Physiological Society]
日期:2024-06-19
标识
DOI:10.1152/ajpendo.00035.2024
摘要
Retinol saturase (RetSat) is an oxidoreductase involved in lipid metabolism and the cellular sensitivity to peroxides. RetSat is highly expressed in metabolic organs like liver and adipose tissue and its global loss in mice increases body weight and adiposity. The regulation of RetSat expression and its function in the intestine are unexplored. Here, we show that RetSat is present in different segments of the digestive system, localizes to intestinal epithelial cells, and is upregulated by feeding mice high-fat diet (HFD). Intestine-specific RetSat deletion in adult mice did not affect nutrient absorption and energy homeostasis basally, but lowered body weight gain and fat mass of HFD-fed mice, potentially via increasing locomotor activity. Moreover, jejunal expression of genes related to β-oxidation and cholesterol efflux were decreased and colonic cholesterol content reduced upon RetSat deletion. In colitis, which we show to downregulate intestinal RetSat expression in humans and mice, RetSat ablation improved epithelial architecture of the murine colon. Thus, intestinal RetSat expression is regulated by dietary interventions and inflammation, and its loss reduces weight gain upon HFD-feeding and alleviates epithelial damage upon injury.
科研通智能强力驱动
Strongly Powered by AbleSci AI