材料科学
药物输送
纳米材料
超声波
纳米技术
药品
生物医学工程
靶向给药
药理学
医学
放射科
作者
Ssu-Chi Lin,Ravindra Joshi,Anindita Ganguly,Snigdha Roy Barman,Arnab Pal,Kuldeep Kaswan,Kuei-Lin Liu,Amit Nain,Fu‐Cheng Kao,Zong‐Hong Lin
出处
期刊:Nano Energy
[Elsevier]
日期:2024-08-01
卷期号:127: 109732-109732
标识
DOI:10.1016/j.nanoen.2024.109732
摘要
Traditional drug delivery systems lack the potential of controlled drug release, thereby decreasing drug utilization and release efficiency. Herein, a next generation of stimuli-responsive drug delivery platform is designed based on piezocatalytic molybdenum disulfide nanoflowers (MoS2 NFs) which can be triggered by ultrasound (US) stimulation for effective acute inflammation therapy. Under US irradiation, MoS2 NFs undergoes piezocatalysis to generate reactive oxygen species (ROS) owing to piezoelectric polarization, thus releasing loaded anti-inflammatory drug Indomethacin (IND) to the targeted inflammation site. The cumulative release of IND elevated significantly with the increase in the duration for US exposure due to the amplified ROS generation, which displayed a highly controllable nature of the as-designed drug delivery platform. For convenient applications, the IND loaded MoS2 NFs (IND@MoS2 NFs) was functionalized onto commercial dressings and their tunable in-vivo drug release performance was demonstrated in paw edema model. IND@MoS2 NFs upon US irradiation, controllably released IND into the site-specific inflamed paw which significantly inhibited 56% of paw swelling in 6 h by suppressing the infiltration of neutrophils and expression of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α). The highly controllable drug delivery system holds great potential in facilitating personalized, user-friendly theranostic applications with improved patient outcomes.
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