生物
基因组
核心
细胞质
细胞皮质
DNA
核糖核酸
细胞生物学
细胞核
微管
遗传学
细胞
病毒学
基因
细胞骨架
作者
Camila E. Osega,Fernando J. Bustos,Gloria Arriagada
出处
期刊:Annual Review of Virology
[Annual Reviews]
日期:2024-06-07
标识
DOI:10.1146/annurev-virology-100422-023502
摘要
Once inside host cells, retroviruses generate a double-stranded DNA copy of their RNA genomes via reverse transcription inside a viral core, and this viral DNA is subsequently integrated into the genome of the host cell. Before integration can occur, the core must cross the cell cortex, be transported through the cytoplasm, and enter the nucleus. Retroviruses have evolved different mechanisms to accomplish this journey. This review examines the various mechanisms retroviruses, especially HIV-1, have evolved to commute throughout the cell. Retroviruses cross the cell cortex while modulating actin dynamics and use microtubules as roads while connecting with microtubule-associated proteins and motors to reach the nucleus. Although a clearer picture exists for HIV-1 compared with other retroviruses, there is still much to learn about how retroviruses accomplish their commute.
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