Synthesis of vanadium pentoxide nanoparticles via laser ablation for biomedical applications

In recent years, vanadium pentoxide (V 2 O 5 ) nanoparticles (NPs) have attracted considerable interest due to their potential medicinal applications, including cancer therapy, antibiotic resistance and antibacterial activity. Manufacturing V 2 O 5 NPs is a crucial step in developing these applications, and laser ablation in solution has proven to be a particularly successful technique. Following fabrication, colloidal solutions were analyzed using ultraviolet–visible (UV–Vis) absorption spectra, Fourier transform infrared (FTIR) spectrum, transmission electron microscopy (TEM) and X-ray diffraction (XRD). In this work, XRD study revealed that the produced NPs had an orthorhombic phase. Based on the laser energy, nanosized vanadium pentoxide particles were created by laser irradiating a vanadium bulk submerged in a double deionized water (DDW), resulting in spherical particles with average sizes ranging from 15.4 to 33.8[Formula: see text]nm, as shown by TEM micrographs. Conforming to the quantum size concept, the bandgap energy of V 2 O 5 NPs is higher than that of bulk V 2 O 5 due to the decrease in particle size. This study examined the effectiveness of V 2 O 5 NPs against pathogenic bacterial strains Staphylococcus aureus as Gram’s positive bacteria and Escherichia coli as negative Gram’s bacteria. Then, we evaluated anticancer activity of V 2 O 5 NPs against a breast cancer cell line (MCF-7 cells) using MTT assay. The results reveal that the activity of prepared V 2 O 5 NPs against S. aureus is greater than that of E. coli. The findings suggest that prepared NPs can act as an anti-proliferative agent against MCF-7 cells. Subsequently, the produced NPs might be exploited as a future strategy for other biomedical applications.