Cuspal Shape Alterations by Bmp4 Directing Cell Proliferation and Apoptosis

形态发生 细胞生物学 生物 细胞生长 细胞凋亡 细胞 细胞周期 基因 遗传学
作者
Eun Jin Kim,Kim Hy,Li L,Qingfeng Tang,Keun Su Kim,Hayato Ohshima,Han‐Sung Jung
出处
期刊:Journal of Dental Research [SAGE]
卷期号:102 (7): 825-834
标识
DOI:10.1177/00220345231167769
摘要

The enamel knot (EK), located at the center of cap stage tooth germs, is a transitory cluster of nondividing epithelial cells. The EK acts as a signaling center that provides positional information for tooth morphogenesis and regulates the growth of tooth cusps. To identify species-specific cuspal patterns, this study analyzed the cellular mechanisms in the EK that were related to bone morphogenetic protein (Bmp), which plays a crucial role in cell proliferation and apoptosis. To understand the cellular mechanisms in the EK, the differences between 2 species showing different cuspal patterning, mouse (pointy bunodont cusp) and gerbil (flat lophodont cusp), were analyzed with quantitative reverse transcriptase polymerase chain reaction and immunofluorescent staining. Based on these, we performed protein-soaked bead implantation on tooth germs of the 2 different EK regions and compared the cellular behavior in the EKs of the 2 species. Many genes related with cell cycle, cell apoptosis, and cell proliferation were involved in BMP signaling in the EK during tooth development. A comparison of the cell proliferation and apoptosis associated with Bmp revealed distinctive patterns of the cellular mechanisms. Our findings indicate that the cellular mechanisms, such as cell proliferation and apoptosis, in the EK are related to Bmp4 and play an important role in tooth morphogenesis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
几酌应助JL采纳,获得10
1秒前
黎明完成签到,获得积分10
1秒前
qks完成签到 ,获得积分10
2秒前
爆米花应助Jeffery426采纳,获得10
2秒前
2秒前
3秒前
3秒前
leoan完成签到,获得积分10
5秒前
Orange应助科研民工采纳,获得10
6秒前
ademwy发布了新的文献求助10
7秒前
8秒前
karenli发布了新的文献求助10
8秒前
10秒前
normankasimodo完成签到,获得积分10
12秒前
12秒前
落寞傲南发布了新的文献求助10
13秒前
Smoiy完成签到 ,获得积分10
13秒前
14秒前
xizhoulls发布了新的文献求助10
14秒前
14秒前
14秒前
fat完成签到,获得积分10
18秒前
顺心靖雁发布了新的文献求助10
18秒前
Carlyle发布了新的文献求助10
19秒前
botanist完成签到 ,获得积分10
19秒前
小石发布了新的文献求助10
19秒前
十月的天空完成签到,获得积分10
19秒前
20秒前
22秒前
美嘉美完成签到,获得积分10
24秒前
xxx完成签到,获得积分10
25秒前
我是老大应助ademwy采纳,获得10
25秒前
28秒前
28秒前
30秒前
raininjuly给raininjuly的求助进行了留言
33秒前
科研通AI2S应助小董不懂采纳,获得10
33秒前
star009发布了新的文献求助10
34秒前
35秒前
渐入佳境完成签到,获得积分20
35秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3162863
求助须知:如何正确求助?哪些是违规求助? 2813883
关于积分的说明 7902296
捐赠科研通 2473504
什么是DOI,文献DOI怎么找? 1316868
科研通“疑难数据库(出版商)”最低求助积分说明 631545
版权声明 602187