化学
铑
催化作用
芳基
药物化学
键裂
劈理(地质)
功能群
组合化学
立体化学
有机化学
烷基
聚合物
岩土工程
断裂(地质)
工程类
作者
Wenxi Chen,Yan Mao,Min Wang,Fei Ling,Changchang Li,Zhangpei Chen,Jinzhong Yao
摘要
A rhodium-catalyzed formal [4 + 1]-cyclization reaction of aryl substituted pyrazoles with cyclopropanols via C-H bond activation/cyclization processes to selectively construct a series of carbonyl functionalized pyrazolo[5,1-a]isoindoles is described. The reaction features good functional group compatibility and a broad substrate scope with respect to both cyclization components with up to 84% yields. Mechanistic studies indicated that the C-H cleavage might be the rate-determining step in this transformation.
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