The effect of inflammation markers on cortical thinning in major depressive disorder: A possible mediator of depression and cortical changes

重性抑郁障碍 扣带回前部 神经炎症 心理学 内科学 萧条(经济学) 医学 神经科学 肿瘤科 炎症 扁桃形结构 认知 经济 宏观经济学
作者
Youbin Kang,Daun Shin,Aram Kim,Sung‐Hye You,Byungjun Kim,Kyu‐Man Han,Byung‐Joo Ham
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:348: 229-237 被引量:7
标识
DOI:10.1016/j.jad.2023.12.071
摘要

Major depressive disorder (MDD) is a prevalent mental health condition with significant societal impact. Owing to the intricate biological diversity of MDD, treatment efficacy remains limited. Immune biomarkers have emerged as potential predictors of treatment response, underscoring the interaction between the immune system and the brain. This study investigated the relationship between cytokine levels and cortical thickness in patients with MDD, focusing on the corticolimbic circuit, to elucidate the influence of neuroinflammation on structural brain changes and contribute to a deeper understanding of the pathophysiology of MDD. A total of 114 patients with MDD and 101 healthy controls (HC) matched for age, sex, and body mass index (BMI) were recruited. All participants were assessed for depression severity using the Hamilton Depression Rating Scale (HDRS), and 3.0 T T1 weighted brain MRI data were acquired. Additionally, cytokine levels were measured using a highly sensitive bead-based multiplex immunosorbent assay. Patients diagnosed with MDD exhibited notably elevated levels of interleukin-6 (p = 0.005) and interleukin-8 (p = 0.005), alongside significant cortical thinning in the left anterior cingulate gyrus and left superior frontal gyrus, with these findings maintaining significance even after applying Bonferroni correction. Furthermore, increased interleukin-6 and interleukin-8 levels in patients with MDD are associated with alterations in the left frontomarginal gyrus and right anterior cingulate cortex (ACC). This suggests a potential influence of neuroinflammation on right ACC function in MDD patients, warranting longitudinal research to explore interleukin-6 and interleukin-8 mediated neurotoxicity in MDD vulnerability and brain morphology changes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
Ceka完成签到,获得积分10
2秒前
3秒前
3秒前
hyl完成签到,获得积分10
4秒前
积极的初南完成签到,获得积分10
5秒前
Livrik发布了新的文献求助10
6秒前
小小完成签到 ,获得积分10
6秒前
笨笨山芙发布了新的文献求助10
7秒前
8秒前
8秒前
9秒前
9秒前
10秒前
11秒前
量子星尘发布了新的文献求助10
12秒前
Livrik完成签到,获得积分10
12秒前
小猴子关注了科研通微信公众号
12秒前
阿Q完成签到,获得积分10
13秒前
yujd完成签到,获得积分10
13秒前
鹿仪发布了新的文献求助10
13秒前
13秒前
13秒前
Orange应助好宝宝采纳,获得10
15秒前
15秒前
GL发布了新的文献求助10
16秒前
16秒前
李健应助年轻的烨华采纳,获得10
18秒前
Jasper应助zhugepengju采纳,获得10
18秒前
19秒前
酢浆草小熊完成签到 ,获得积分10
19秒前
沈昊泽完成签到,获得积分10
22秒前
陈浩发布了新的文献求助10
22秒前
23秒前
春眠不觉小小酥完成签到,获得积分10
24秒前
25秒前
26秒前
26秒前
wwb完成签到,获得积分10
26秒前
在水一方应助meimale采纳,获得10
27秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035