Efficient Construction of pH-Stimuli-Responsive Colloidosomes with High Encapsulation Efficiency

纳米技术 材料科学 甲基丙烯酸 化学 聚合物 共聚物 复合材料
作者
Jia Jia,Rongkun Liu,Qian Sun,Jie‐Xin Wang
出处
期刊:Langmuir [American Chemical Society]
卷期号:39 (49): 17808-17817 被引量:2
标识
DOI:10.1021/acs.langmuir.3c02415
摘要

Intelligent responsive colloidosomes have attracted increasing attention for their potential to enhance the efficacy and decrease the side effects of drugs in biomedical applications. However, a low encapsulation efficiency and complicated preparation method greatly limit their development. Herein, we report an efficient approach for the construction of pH-stimuli-responsive colloidosomes with high encapsulation efficiency by a high-gravity technology. The conditions under which latex particles with different methacrylic acid contents can successfully self-assemble into colloidosomes are explored. During the preparation process, emulsions emulsified for only 10 min at 2500 rpm in a unique high-gravity shearing surroundings are clarified owing to the greatly enhanced micromixing, while the emulsions emulsified for 30 min by a traditional high-speed shear machine at 4000 rpm are still yellow–white. More importantly, regular spherical colloidosomes encapsulating an anticancer drug doxorubicin not only achieve a small mean diameter of 2.82 μm but also realize a high encapsulation efficiency of 76.5%. The release performance of doxorubicin has an obvious pH-stimuli-responsive regularity and follows the first-order model of sustained release. The construction of intelligent responsive colloidosomes as drug carriers provides a route for controlled drug release and biomedical applications.
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