Development and Optimization of a Target Engagement Model of Brain IDO Inhibition for Alzheimer’s Disease
疾病
神经科学
心理学
医学
病理
作者
Kurt R. Stover,Paul M. Stafford,Andreea C Damian,Jagadeesh Prasad Pasangulapati,Jake Goodwin‐Tindall,Lucía M. López Vásquez,Sanghyun Lee,Seung‐Pil Yang,Mark A. Reed,Christopher Barden,Donald F. Weaver
Indoleamine 2,3-dioxygenase (IDO1) inhibition is a promising target as an Alzheimer's disease (AD) Disease-modifying therapy capable of downregulating immunopathic neuroinflammatory processes.
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