Plants under changing conditions release different blends of root exudates, which can play key role in modulating rhizospheric microbiome and soil nutrient cycling. Correlational network analysis of stress alleviated root exudate compounds with the different rhizospheric microbes, depicts a significant relationship of plant associated microbes and exuded chemicals during stress condition/alleviation. Therefore, understanding the root associated structural and functional attributes with respect to the change in the environmental factors, modulating rhizospheric microbiome is utmost necessary. Here, we highlight the current knowledge of abiotic stress induced alteration in root exudates composition; and resulting modulation in the rhizospheric microbiome to alleviate plants from stress regimes. Understanding plant-root exudation-microbiome dynamics during stress condition can provide a way to develop innnovative solutions that can revolutionize sustainable agriculture.