痛苦
生物
免疫
抗体
对抗
细胞生物学
神经科学
免疫学
计算生物学
免疫系统
受体
遗传学
政治
政治学
法学
出处
期刊:Immunity
[Elsevier]
日期:2024-02-01
卷期号:57 (2): 193-195
标识
DOI:10.1016/j.immuni.2024.01.015
摘要
Different antibodies can bind to the same targets on the surface of immune cells with opposite biologic effects. These effects—agonism, antagonism, or partial agonism—are so poorly understood that drug developers must screen antibodies for relevant desired characteristics. In this issue of Immunity, Lippert et al. define molecular mechanisms that dictate antibody behavior, ushering in an era of directed antibody design. Different antibodies can bind to the same targets on the surface of immune cells with opposite biologic effects. These effects—agonism, antagonism, or partial agonism—are so poorly understood that drug developers must screen antibodies for relevant desired characteristics. In this issue of Immunity, Lippert et al. define molecular mechanisms that dictate antibody behavior, ushering in an era of directed antibody design. Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatasesLippert et al.ImmunityFebruary 13, 2024In BriefAntibodies can initiate immune receptor signaling. Lippert et al. provide mechanistic insight into this effect, showing that antibody agonists trigger receptor signaling by locally excluding receptor-type protein tyrosine phosphatases from sites of antibody-receptor engagement. This finding provides a framework for the engineering of therapeutic antibodies. Full-Text PDF Open Access
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