药品
胰岛素
药物输送
控制释放
化学
生物医学工程
芯(光纤)
药理学
材料科学
医学
纳米技术
内科学
复合材料
作者
Ye He,Nanxi Chen,Mingming Zang,Jinghai Zhang,Youxi Zhang,Hongyan Lu,Qinfu Zhao,Yuling Mao,Yue Yuan,Siling Wang,Yikun Gao
标识
DOI:10.1016/j.jconrel.2024.03.001
摘要
Limited drug loading and incomplete drug release are two major obstacles that traditional polymeric microneedles (MNs) have to overcome. For smart controlled-release MNs, since drug release duration is uncertain, a clear indication of the finish of drug release is also important for patient guidance on the timing of the next dose. In this study, MN with a triple structure of a glucose-responsive shell, loaded insulin powders and a colored propelling inner core (inspired by the mechanism of osmotic pump) was innovatively constructed. The MN patch could release insulin according to blood glucose levels (BGLs) and had excellent drug loading, more complete drug release, and good drug stability, which significantly prolonged the normoglycemic time. An approximately 0.3 cm2 patch has a hypoglycemic effect on diabetic mice for up to 24 h. Moreover, the fading of the inner core could indicate the release process of the loaded drug and can help to facilitate uninterrupted closed loop therapy for patients. The designed triple MN structure is also suitable, and can be used in the design of other smart MN drug delivery systems to further improve their drug loading capacity and simultaneously achieve more complete, smart controlled and visualized drug release.
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