Systemic exposure of floxuridine after hepatic arterial infusion pump chemotherapy with floxuridine in patients with resected colorectal liver metastases

氟尿苷 医学 相伴的 化疗 肝动脉灌注 氟尿嘧啶 胃肠病学 结直肠癌 内科学 癌症
作者
Nikki S. IJzerman,W.F. Filipe,Peter de Bruijn,Florian E. Buisman,Leni van Doorn,Pascal G. Doornebosch,Jessica J. Holster,Cecile Grootscholten,Dirk J. Grünhagen,Christian P.E. van Bommel,Marjolein Y.V. Homs,Niels F. M. Kok,Cornelis Verhoef,Bas Groot Koerkamp,Koert Kuhlmann,Ron H.J. Mathijssen,Stijn L.W. Koolen
出处
期刊:Biomedicine & Pharmacotherapy [Elsevier]
卷期号:162: 114625-114625
标识
DOI:10.1016/j.biopha.2023.114625
摘要

Background: Floxuridine's high hepatic extraction ratio and short elimination half-life allows maximum liver exposure with minimal systemic side-effects.This study attempts to quantify the systemic exposure of floxuridine.Methods: Patients undergoing continuous hepatic arterial infusion pump (HAIP) floxuridine after resection of colorectal liver metastases (CRLM) in two centres underwent six cycles of floxuridine at start dose 0.12 mg/kg/ day.No concomitant systemic chemotherapy was administered.Peripheral venous blood samples were drawn during the first two cycles: pre-dose (only in the second cycle), 30 min, 1 h, 2 h, 7 h, and 15 days after floxuridine infusion.Foxuridine concentration in the residual pump reservoir was measured on day 15 of both cycles.A floxuridine assay with a lower boundary of detection of 0.250 ng/mL was developed.Results: 265 blood samples were collected in the 25 patient included in this study.Floxuridine was mostly measurable at day 7 and day 15 (86 % and 88 % of patients respectively).The median dose corrected concentrations were 0.607 ng/mL [IQR: 0.472-0.747]for cycle 1 day 7, 0.579 ng/mL [IQR: 0.470-0.693]for cycle 1 day 15, 0.646 ng/mL [IQR: 0.463-0.8546]for cycle 2 day 7, and 0.534 ng/mL [IQR: 0.4257-0.7075]for cycle 2 day 15.One patient had remarkably high floxuridine concentrations reaching up to 44 ng/mL during the second cycle, without a clear explanation.The floxuridine concentration in the pump decreased by 14.7 % (range 0.5 %-37.8 %) over a period of 15 days (n = 18).Conclusion: Overall, negligible systemic concentrations of floxuridine were detected.However, remarkably increased levels were detected in one patient.Floxuridine concentration in the pump decreases over time.
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