纳米颗粒
体内
磁共振成像
核磁共振
材料科学
磁共振造影剂
降水
胶体
磁性纳米粒子
钆
粒径
磁铁
纳米技术
化学
有机化学
物理化学
生物技术
气象学
医学
冶金
量子力学
生物
放射科
物理
作者
Elisabet Gómez-González,Carlos Caro,Diego Martínez-Gutiérrez,Maria Luisa García‐Martín,Manuel Ocaña,Ana Isabel Becerro
标识
DOI:10.1016/j.jcis.2020.11.119
摘要
The increasing use of high magnetic fields in magnetic resonance imaging (MRI) scanners demands new contrast agents, since those used in low field instruments are not effective at high fields. In this paper, we report the synthesis of a negative MRI contrast agent consisting of HoPO4 nanoparticles (NPs). Three different sizes (27 nm, 48 nm and 80 nm) of cube-shaped NPs were obtained by homogeneous precipitation in polyol medium and then coated with poly(acrylic) acid (PAA) to obtain stable colloidal suspensions of HoPO4@PAA NPs in physiological medium (PBS). The transverse relaxivity (r2) of aqueous suspensions of the resulting NPs was evaluated at both 1.44 T and 9.4 T. A positive correlation between r2 values and field strength as well as between r2 values and particle size at both magnetic field strengths was found although this correlation failed for the biggest NPs at 9.4 T, likely due to certain particles aggregation inside the magnet. The highest r2 value (489.91 mM-1s−1) was found for the 48 nm NPs at 9.4 T. Toxicity studies demonstrated that the latter NPs exhibited low toxicity to living systems. Finally, in vivo studies demonstrated that HoPO4@PAA NPs could be a great platform for next-generation T2-weighted MRI contrast agents at high magnetic field.
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