Attach importance to the immunological mechanism of preeclampsia

Preeclampsia is one of the main causes of high morbidity and mortality of pregnant women and perinatal infants worldwide. Affected by many factors, preeclampsia has a complex pathogenesis and can cause involvement of multiple organs and systems. Its pathogenesis is still unclear. Current research suggests that maternal immune system indirectly involved in the pathophysiology of preeclampsia change, that is, abnormal activation of innate immune cells and unbalanced differentiation of T helper cell subsets interfere with normal immune regulation, and interact with inflammatory response of the body, which produces cytotoxic environment at the maternal-fetal interface and affects trophoblast invasion. Therefore, clarifying the role of the immune system can not only clarify the pathogenesis of preeclampsia, but also contribute to the development of diagnosis and treatment of preeclampsia. This paper reviews the research status of immune system in preeclampsia, including innate immunity and adaptive immunity. The immune mechanism of preeclampsia is elaborated mainly from immune regulation mediated by T lymphocyte, natural killer (NK) cell, macrophage and human leukocyte antigen. Key words: Pre-eclampsia; Th1-Th2 balance; Th17 cells; T-lymphocytes, regulatory; Killer cells, natural; Macrophages; HLA antigens