已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

The relationship between residual cholesterol risk and plaque characteristics in patients with acute coronary syndrome: Insights from an optical coherence tomography study

医学 急性冠脉综合征 内科学 纤维帽 胆固醇 入射(几何) 心脏病学 光学相干层析成像 胃肠病学 放射科 心肌梗塞 光学 物理
作者
Yanan Gao,Yake Lou,Yuyang Liu,Sijing Wu,Ziwei Xi,Xu Wang,Yujie Zhou,Wei Liu
出处
期刊:Atherosclerosis [Elsevier BV]
卷期号:317: 10-15 被引量:8
标识
DOI:10.1016/j.atherosclerosis.2020.11.033
摘要

Background and aims The impact of residual cholesterol risk (RCR) on plaque characteristics is not fully understood. The study aims to explore the relationship between RCR and plaque features in patients presenting with acute coronary syndrome (ACS). Methods All ACS patients undergoing pre-intervention optical coherence tomography (OCT) with high-sensitivity C-reactive protein (hs-CRP) <2 mg/L on admission were retrospectively enrolled from January to December 2017, at Beijing Anzhen Hospital, Capital Medical University. RCR was defined as low density lipoprotein cholesterol (LDL-C) ≥1.8 mmol/L. Patients were divided into the RCR and non-RCR groups according to baseline LDL-C. Results A total of 90 patients (94 vessels) were included, with 50 in the RCR group and 40 in the non-RCR group, respectively. Compared with the non-RCR group, patients in the RCR group were younger (54.0 ± 11.04 vs. 58.4 ± 9.59, p = 0.049) and had a higher incidence of multivessel disease (6.0% vs. 2.5%, p = 0.028). With regard to plaque characteristics, fibrous plaque (0.0% vs 12.5%, p = 0.003) was less and fibroatheroma (79.6% vs. 50.0%, p = 0.028) was more frequently seen in the RCR group. Patients in the RCR group were more prone to present with plaque rupture (24.1% vs 5.0%, p = 0.008). Cholesterol crystal (22.2% vs 12.5%, p = 0.226) and thin-cap fibroatheroma (25.9% vs. 12.5%, p = 0.109) were more common in the RCR group, though without statistical difference. Multivariate logistic regression showed that RCR (odds ratio [OR]: 7.95, p = 0.011) and smoking (OR: 4.08, p = 0.026) were independent risk factors of plaque rupture in our patients. Conclusions ACS patients with RCR are more likely to have atherosclerotic plaque and plaque rupture, indicating a more vulnerable plaque phenotype.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Ava应助xia采纳,获得10
3秒前
思源应助小方采纳,获得10
4秒前
董思雨完成签到 ,获得积分20
7秒前
ZZZ完成签到 ,获得积分10
7秒前
多发论文完成签到,获得积分10
7秒前
FashionBoy应助给大佬递茶采纳,获得10
8秒前
8秒前
dinner完成签到,获得积分20
8秒前
9秒前
10秒前
12秒前
奶片发布了新的文献求助10
14秒前
Gwaising应助zhangmeimei采纳,获得10
14秒前
桑叶发布了新的文献求助10
15秒前
Jemma发布了新的文献求助10
16秒前
dramarama720发布了新的文献求助10
17秒前
华仔应助hyr采纳,获得10
18秒前
团结友爱完成签到,获得积分10
18秒前
阳光和煦轻风拂面完成签到,获得积分10
20秒前
康康完成签到,获得积分10
20秒前
allshestar完成签到 ,获得积分0
22秒前
上官若男应助给大佬递茶采纳,获得10
24秒前
ccccc1998完成签到,获得积分10
24秒前
25秒前
Ava应助科研通管家采纳,获得10
27秒前
赘婿应助科研通管家采纳,获得10
27秒前
小蘑菇应助科研通管家采纳,获得10
27秒前
27秒前
NexusExplorer应助科研通管家采纳,获得10
27秒前
27秒前
27秒前
ding应助科研通管家采纳,获得10
27秒前
27秒前
小海狸完成签到,获得积分20
28秒前
czh关注了科研通微信公众号
29秒前
小海狸发布了新的文献求助30
31秒前
32秒前
32秒前
胡洁媛发布了新的文献求助10
34秒前
36秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976455
求助须知:如何正确求助?哪些是违规求助? 3520548
关于积分的说明 11203850
捐赠科研通 3257210
什么是DOI,文献DOI怎么找? 1798648
邀请新用户注册赠送积分活动 877835
科研通“疑难数据库(出版商)”最低求助积分说明 806539