Wearable sensors for continuous oral cavity and dietary monitoring toward personalized healthcare and digital medicine

Oral monitoring plays an essential role in preventing and diagnosing systemic diseases through saliva in the mouth. Dietary monitoring is also crucial to reduce the likelihood of chronic diseases such as hypertension and diabetes by analyzing food types, amounts and diet patterns. Therefore, the oral cavity and dietary monitoring are vital for accurate personalized healthcare management that can improve healthcare. To perform continuous oral cavity and dietary monitoring in real-time, a wearable sensing system capable of continuous analysis is necessary. In this review, we classify chemical and physical biosensing methods and summarize recent progress in wearable sensor development for oral cavity and dietary monitoring for personalized healthcare and digital medicine. We also discuss future perspectives and the potential of wearable sensors to provide robust data for food-intake monitoring and the saliva analysis of super-aged/aging societies, non-face-to-face social life, and global pandemic disease issues. We believe that this review will result in a paradigm shift toward personalized healthcare and digital medicine using wearable sensors through the analysis of massively parallel healthcare data.